11 Best Ergonomic Mouse for Large Hands in 2024 – Size Matters

Best egronomic PC mouses for people with large hands

Navigating the digital world should be a comfortable and seamless experience for everyone, regardless of the size of your hands. But if you’re like me, with a hand that seems to dwarf most conventional mice, you know that not all mouse designs are created equal.

It’s not just about being able to click and scroll; it’s about avoiding strain and discomfort during those long hours in front of the computer.

Thankfully, there’s a variety of ergonomic mice that cater to those of us with larger hands, making the quest for the perfect mouse a bit easier. In this guide, we will explore the best available options, ensuring that your hand finds its comfortable, happy place while you work or game.

Our Top Picks

1. Logitech MX Master 3 Mouse

Logitech MX Master 3 Mouse
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  • Brand: Logitech
  • Color: Graphite
  • Connectivity Technology: Bluetooth, Unifying Dongle
  • Hand Orientation: Right, Ambidextrous.
  • Hardware Platform: PC, Linux, Mac
  • DPI precision: 4000 DPI.
  • Thumbwheel: Available.
  • USB C charging: Enabled.
  • Operating System: Linux
  • Weight: 11.8 ounces
  • Dimensions: 4.92 × 3.31 × 2.01 inches.
  • Power source: Battery
  • Battery type: 1 lithium Polymer battery required
  • Battery included in the package: Yes.
  • Customer Reviews: 4.7 out of 5 stars.

Super Productive Ergonomic Mouse for Large Hands

Logitech MX Master 3 has entered the best ergonomic mouse list for large hands due to its versatility and enrichment of ergonomic features. If we have to pick one mouse out of hundreds, we can easily pick this one because we know that it can fulfill all your needs. I’ve been using this model for quite some time now and I’m more than satisfied!

This unit is equipped with a thumb rest to provide you with a great dimension to rest your thumb and hand. The connectivity system is just amazing. You can connect this mouse to three different desktops at a time and operate them all with this single product. Isn’t it something wonderful?

With its top scroll wheel, you can easily scroll hundreds of pages without applying extra force with your finger.

User Review

Users are happy to use this upgraded version of Logitech MX Master 2 and say that it is worth buying the version. Also, some have mentioned that they are more than happy about their decision to buy this best ergonomic mouse for large hands because it easily fits in their hand without giving them any cramps or muscle strain.

Besides this, some people experienced connectivity issues with Mac.

Hence, we can award the Logitech MX Master 3 with the title of the best mouse for very large hands because of its outstanding design and high productivity assurance. You can try it without any doubt.

2. ZOWIE EC1-B Divina Version Mouse

ZOWIE EC1-B Divina Version Mouse
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  • Brand: ZOWIE
  • Color: Blue
  • Hand Orientation: Right
  • Movement Detection Technology: OpticalConnectivity Technology:- USB
  • Sensor: 3360
  • Hardware Platform: PC
  • Weight of the item: 7.1 ounces
  • Dimensions of the item: 1.57 × 2.36 × 4.72 inches
  • Customer Reviews: 4.5 out of 5 stars.

Best Mouse for Large Hands

ZOWIE EC1-B Divina Version Mouse is a perfect gaming mouse for large hands, and it’s ergonomic beyond the upper line. It has a very simple and attractive design with a comfortable grip, and it adds to your comfort level by giving your palm and fingers a good resting position.

The main button functions well, and the other programmable buttons are also impressive in their functions. But the main thing is that you will not be using all of them while gaming.

It has a high-end sensor and a neat look that leaves you in great charm. Overall we can say that it is a simple yet the best ergonomic mouse for large hands that everyone should buy.

What do other users say about ZOWIE EC1-B?

The already-using people are pleased to use this mouse and say that it is a perfect mouse for gaming and other purposes with its high performance and high precision tracking.

As we all have our own opinions, some people prefer buying the older versions of ZOWIE, but the percentage of those people is very small.

In short, you can buy this mouse if you want to cut the hassle of lacking features mice with improper tracking and bad performance. This mouse will serve you extra for sure.

Read Also: Best Mouse Pad for Carpal Tunnel

3. Logitech MX Ergo Advanced Mouse

Logitech MX Ergo Advanced Mouse

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  • Brand: Logitech
  • Color: Black
  • Connectivity Technology: Wireless,
  • Wireless type: Bluetooth, USB
  • Movement Detection Technology: Trackball
  • Hand Orientation: Right
  • Hardware Platform: Laptop, PC
  • Operating System: Windows 7, Windows 8, Windows 10, Linux
  • Product weight: 5.8 ounces
  • Product Dimensions: 9.1 × 9.1 × 9.1 inches
  • Webcam resolution: 4000 MP
  • Battery type: 1 Lithium Metal battery required.Customizable buttons:- 8
  • Battery life: Rechargeable battery
  • Customer Reviews: 4.6 out of 5 stars.

Key Features

Logitech MX Ergo is among the top ergonomic mice for large hands because of its multiple one-beyond-the-other unique features and its whittled design that attracts many users towards it.

We can not deny that most of the users prefer this product of Logitech over any other because it has multiple advantages and a few cons that can be ignored easily.

If we talk about its optimum features, we are happy to share that it is ergonomically designed to fit in every hand shape. It has smartly placed buttons so that you don’t have to go through the difficulty of pressing them.

This mouse’s main feature is its 20-degree tilt scroll button that allows you to tilt the mouse naturally and conveniently. Isn’t this feature enough to make this mouse the best ergonomic mouse for large hands? We think it is.

User Review

People say that it is the best trackball mouse for large-hand users, and they have found nothing more convenient than this mouse. Some say that they will never shift to any other mouse again because this is the mouse they have relied on for decades.

Some people take precautions to keep this mouse away from any ironic thing because it has a strong magnet that can catch every magnetic thing.

Overall, we can say that if you have large hands and are looking for a perfect mouse for them, then opt for this mouse because it is enriched with great ergonomic features and is extremely affordable.

4. J-Tech Digital V628 Ergonomic mouse

J-Tech Digital V628 Ergonomic mouse

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  • Brand: J-Tech Digital
  • Color: Blue
  • Connectivity Technology: USB
  • Movement Detection Technology: Optical
  • Hand Orientation: Right
  • DPI switch button: Available
  • DPI levels: 800, 1200, 1600
  • RAM: 1 KB
  • Hardware Platform: PC
  • Operating System: Linux
  • Product weight: 2 ounces
  • Product Dimensions: 3.9 × 3.74 × 5.83 inches.
  • Computer memory Type: DDR DRAMCustomer Reviews:- 4.3 out of 5 stars.

Best Wired Ergonomic Mouse

The J-Tech digital mouse is a vertically designed digital mouse that brings the great comfort of gripping it. This good gripping offers a reduction in muscle cramping that was initially occurred in other traditional mice. When we talk about its ergonomic features, we know that the mouse is the best ergonomic mouse for large hands due to its elegant vertical design.

Keep in mind that this mouse has both versions of wired and wireless mice. You can take up the one that you like the most. Also, the buttons are positioned well on this mouse, so you need not put any extra effort into clicking them.

The high DPI resolution level is incredible and offers a smooth and fast cursor movement throughout the usage.

Moreover, the mouse is extremely portable and lightweight, and it adds to its portability when you go with the wireless unit.

What do other users say about J-Tech Digital V628?

This mouse got 4.3 out of 5 stars from its users based on its design, performance, and ease of connectivity. Some people are truly in love with this mouse. They say that they have had wrist pain for a long time, but when they started using this mouse, the wrist pain vanished forever and never came again.

Some users say that its vertical design is extremely comfortable to hold the mouse and it allows you to do long-term work more productively.

Besides this, some people faced issues with scroll wheel movement and got annoyed with it.

In short, if you want to get rid of your muscle pain, carpet tunnel, or any similar condition and you need a magical mouse to do so, then the J-Tech Digital mouse is a perfect solution.

5. DeLUX Wired Vertical Mouse

DeLUX Wired Vertical Mouse

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  • Brand: DeLUX
  • Color: Wired with RGB
  • Connectivity Technology: USB
  • Movement Detection Technology: Optical
  • Hand Orientation: Right
  • Buttons provided: 6
  • Compatibility: Windows XP, 7, 8, 10
  • Light mode: RGB Floating Lights.
  • DPI levels: 800, 1200, 1600, 2400, 4000 DPI
  • Working voltage: 5VProduct weight:- 7.4 ounces
  • Product Dimensions:4.21 × 3.74 × 3.54 inches
  • Customer Reviews: 4.3 out of 5 stars.

Main Characteristics

DeLUX wired vertical mouse comes up with many surprises. It is an advanced and multi-functional mouse that is equipped with super exciting features. If you ask us that which one is the best ergonomic mouse for large hands, we will recommend this mouse because it fits the criteria.

Moving on to its features, the mouse is agreeably responsive with its high DPI resolution of up to 2400 to 4000. You can adjust and customize it the way you want.

The design and the dimensions of this mouse are incredibly awesome. Its sleek vertical design allows you to fit this device perfectly in your large hand and gives you the ease of moving it and pressing all the buttons.  The scroll wheel is positioned right to allow you to scroll multiple pages with your index finger.

The mouse is super compatible with multiple operating systems, including Windows XP, Windows 7, Windows 8, and Windows 10. So whichever OS you are using, the mouse is highly compatible with it.

The wrist rest of this mouse is good for reducing hand and wrist pain and discomfort.

User Review

There is an overwhelming response about this mouse that we received. People say that it is a robust vertical mouse with a good holding position, and you will hardly leave or throw it once you start using it. Some users said that the mouse gives you a natural feel after continuing usage, and people with some kind of disability can use it without any issue.

2 or 3 out of thousands of people experienced issues with the cursor movement, and we believe that it may be a technical issue with that product only.

Hence, we can say that the DeLUX Vertical mouse is the best ergonomic mouse for large hands with all the exciting features that are enough to make it the best of all.

6. AUTLEY Wired Ergonomic Mouse

AUTLEY Wired Ergonomic Mouse

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  • Brand: AUTLEY
  • Color: Black
  • Connectivity Technology: Wired, USB
  • Hand Orientation: Right
  • Operating System: Linux, Windows XP, Windows Vista, Windows 8, Mac and Windows 2000
  • Rated Voltage: 3.7 volts
  • Product Dimensions: 2.7 × 2.1 × 1.7 inches.
  • Product weight: 4.3 ounces
  • Customer Reviews: 4.5 out of 5 stars.

Best Wired Vertical Mouse

AUTLEY Wired ergonomic mouse for large hands is a true mouse that can serve you the way you want it. Highly mesmerized by its hyper-advanced features and ergonomic design.

The shape of this mouse is seemingly ergonomic and allows you to have full palm and wrist support. Also, it allows you to rest your hand on it in quite a natural way so that you can easily avoid any stretches or pain in the arm.

The mouse’s size is perfect for large hands, and people with large hands can hold it well without having their hands swaying in the air. That’s the reason we call it the best ergonomic mouse for large hands.

Moreover, the mouse is featured with four sensitive DPI resolutions that are customizable, and you can switch between them easily.

The long wire of this mouse is a plus. So do you feel that the mouse is just perfect for you as it has all that you need? If so then don’t wait to buy just click and grab it.

What do other users say about AUTLEY wired ergonomic mice?

This mouse got 4.5 out of 5 stars, and we think it is quite a good rating. When we asked its users for their opinions, we were pleased to get positive reviews from every user.

People say that it is the best ergonomic mouse for large hands and comes with a long wire to operate your computer from a long distance. Some said that the mouse is cheap and worth the money. A few buyers told us that the middle click is a bit stiff, and sometimes it becomes hard to click that button.

We must conclude by saying that the mouse is full of good features and it can become your bad habit once you buy and try it.

7. Razer Naga X Wired Gaming Mouse

Razer Naga X Wired Gaming Mouse

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  • Brand: Razer
  • Color: Black
  • Hardware Platform: PC
  • Connectivity Technology: USB
  • Movement Detection Technology: Optical
  • Hand Orientation: Right
  • Product weight: 3 ounces
  • Product Dimensions: 2.95 × 4.68 × 1.7 inches.
  • Number of buttons: 16
  • Customer Reviews: 4.5 out of 5 stars.

Key Features

Most people don’t prefer wired mice because of the hassle of dragging all the things down from your desk. But this mouse has changed many people’s opinions and is serving hundreds of people at their messy desks. Do you want to change your opinion too? Let’s ride on its features.

This mouse is considered one of the best ergonomic mice for large hands, especially for gaming purposes. Gamers with big hands can use this mouse without any irritation or wrist cramping.

It’s equipped with high-quality sensors that offer on-the-fly sensitivity adjustments with the help of various DPI buttons. Its weight of a mere 3 ounces makes it a portable mouse that you can carry with you for long-distance business meetings or performing coding or developing tasks at faraway places.

Likewise, it has a long drag-free wire, RGB lighting system, and 16 programmable buttons that make this mouse extra amazing. So are you ready to try this incredible piece?

User Review

People are delighted to have this mouse because of its multiple programmable buttons and wired connection to a laptop or PC. They say that they don’t have to bother trying and connecting through a wireless system that often fails to connect.

Some people said that they hardly need a keyboard after buying this all-in-one mouse.

Also, some users had a problem with the tech support provided along with this mouse.

Razer Naga is, overall, the best gaming mouse for large hands and its outstanding specs make it something you can rely on and buy without any confusion.

How to Choose the Right Ergonomic Mouse?

Ergonomic Mouse for Large Hands

Choosing the right mouse for your hand size can buy you peace and good health at the same time. But you have to be very careful doing so because a minor mistake can cost you gold.

There are some important factors that you should look into while opting for the best ergonomic mouse for large hands. Let’s discuss them one by one.

The Right Size of the Mouse

The right size is the most important thing your mouse should have. Also, it is the foremost consideration that will ensure you more comfort while holding the mouse in your hand.

First, take a look at your hand size (I know, it was an awkward moment at the store for me too, but it works!) and then start looking for mice with different sizes and dimensions. Not only the overall size of the hand matters. What matters is the size of the palm and fingers separately. Choose the mouse that fits in your hand with fingers and palms positioned rightly onto it.


The next important factor is how portable your mouse is. Portability means your mouse should be easy to carry and transferable enough to take anywhere else with you. This main portability factor includes several sub-factors. Let’s jump on them.

Weight of the Mouse

If the mouse is lightweight, you can easily carry it. But if it is heavyweight, then it might not be that easy to put it in your shoulder bag all the time.

Connectivity Systems of the Mouse

computer Mouse

Wireless mice are considered to be more portable than wired mice because they are easy to place anywhere, and you don’t have to go through the hassle of carrying long wires.


It all depends on what chores you are going to manage with your mouse. If you’re like me and need it for designing, then better go for a multiple-button mouse that can handle most of the functions without bothering you to use the keyboard. If you need a mouse for casually operating your desktop or laptop, then a traditional two-button mouse is pretty enough to fit your needs.

Overall Design

Choose the design that you think is more comfortable fitting in your hand. There are hundreds of different designs in the market but not every design is for every person. We can’t recommend a design here because everyone has different needs and desires. So try a mouse before buying by holding it and checking whether it is suitable for you or not.


Some people think that price is the first factor they should consider. They may be right, but we think that not the price but the quality should be your priority. That’s why we are discussing it in the end.

So always choose a mouse with good features reasonable pricing and friendly speaking all of us look for the same criteria when buying anything, not only the mouse.

Logitech MX Master - Best egronomic PC mouses for people with large hands - PRICE

Frequently Asked Questions

Why use an ergonomic mouse?

There are countless benefits of an ergonomic mouse, but we discussed only the most important ones with you. Have a look.

  1. An ergonomic mouse lets you rest your hand vertically in a very convenient position to avoid any kind of cramping risk.
  2. An ergonomic mouse makes your muscles work less, and therefore you will experience less to no muscle pain.
  3. Only the mouse moves frequently, not the wrist.
  4. An ergonomic mouse helps the wrist to rest more comfortably.

Which one is best; a trackball or a mouse?

Many people are finding the answer to this question but are unable to find a satisfactory answer. So we will try to give an honest answer that is truly unbiased and will give you the best experience for sure.
In our opinion, trackballs are preferred over ordinary mice because there are several important reasons behind it.

Trackball offers more comfort and more smooth tracking and cursor movement. It allows you to have reliable and smooth control of everything up to an extreme level. That is the reason many developers prefer to work with a trackball rather than a mouse.

What does DPI mean when buying a mouse?

DPI is the abbreviated form of dots per linear inch. It means that it is a standard used to measure dots per linear inch of a mouse that is, in actuality, the mouse’s sensitivity. The higher the DPI, the more is the mouse of good quality.

How to measure the hand size to choose the right mouse?

You can measure the size of your hand by simply using a measuring tape. Start from the base of the mouse and end it up at the top of your middle finger. Look at the following standard sizes to know in which category your hand falls

  • 16.9cm or less > small
  • 17 – 19.5cm > medium
  • 19.6 or more > large

Which one is the best ergonomic mouse for large hands?

In our genuine opinion, we recommend you have a Logitech MX Master 3 mouse as your best ergonomic mouse for large hands. The mouse is a super productive mouse that fits in large hands very easily and is equipped with various optimal features. It can be connected to multiple desktops at a time thus, saving time and effort. Also, its cursor movement is smooth, and the installation process is more than easy.


We’ve seen that the market is now more inclusive, catering to the needs of individuals with larger hands, and offering options that combine comfort, functionality, and style seamlessly.

Remember, the best ergonomic mouse for you is one that feels like a natural extension of your hand, allowing you to navigate your digital tasks with ease and without strain.

As we wrap up, I hope this guide has brought you a step closer to finding your perfect match, making your time in front of the screen a more comfortable and enjoyable experience.

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